OPVEE® frequently
asked questions

OPVEE® is a prefilled, single-dose intranasal spray.¹

OPVEE® is the first and only nasal opioid overdose rescue medicine specifically indicated for synthetic opioids, like fentanyl, as well as nonsynthetic opioids. OPVEE® is for patients 12 years and older and is not a substitute for emergency medical care.¹

Use OPVEE® right away if you think signs or symptoms of an opioid emergency are present, even if you are not sure, because an opioid emergency can cause severe injury or death.¹

If the person does not return to normal breathing, or if their breathing returns but they relapse, an additional dose of OPVEE® can be administered as needed every 2 to 5 minutes.¹

OPVEE® is indicated for the emergency treatment of a known or suspected opioid overdose.¹

OPVEE® is not a substitute for emergency medical care.¹

If you suspect that someone is overdosing, administer OPVEE® as quickly as possible according to the Quick Start Guide and Instructions for Use, which can be found in the full Prescribing Information.¹

While the duration of action of nalmefene is as long as most opioids, seek immediate emergency medical assistance after administration of the first dose of OPVEE®. Keep the person under continued surveillance, even after an apparently adequate initial response to OPVEE® nasal spray treatment. A second dose may be necessary if there is a recurrence of symptoms of opioid overdose.¹

OPVEE® has not been shown to produce tolerance, physical dependence, or abuse potential.¹

People who use opioids regularly may experience precipitated withdrawal (opioid withdrawal symptoms) after administration. The most common adverse effects include¹

• Nose (nasal) discomfort
• Headache
• Nausea
• Dizziness
• Hot flush
• Vomiting
• Anxiety
• Tiredness
• Nasal congestion
• Throat irritation
• Pain in the nose
• Decreased appetite
• Changes in sense of taste
• Skin redness
• Increased sweating

These are not all of the possible side effects of OPVEE®.¹

The safety of OPVEE® is supported by safety and pharmacokinetic studies of OPVEE® in healthy subjects.¹

Precipitated withdrawal is a class effect associated with all opioid rescue medicines, including naloxone, for people with opioid dependence. The symptoms of withdrawal can be medically managed. What cannot be medically managed is irreversible brain damage or death.^1-8

For people without opioid dependence, which includes many of those who have accidentally ingested opioids, precipitated withdrawal is unlikely. This is important given a 2022 review of first responder records in San Francisco, which found that out of 171 opioid overdose cases, 42.7% reported that they did not intend to use opioids.^1-5,9

The OPVEE® Instructions for Use state to “Call 911” after administration.¹

After the person is in medical care, the amount of time for which they are monitored will be dependent on clinical judgment, which could include factors such as the substances in their system and the protocol that is followed by the specific hospital or medical center where the person is receiving care.¹¹

The OPVEE® labeling does not specify the duration of observation following administration.

The active ingredient in OPVEE® is nalmefene 2.7 mg (equivalent to nalmefene hydrochloride [HCl] 3.0 mg) in 0.1 mL solution.¹

Inactive ingredients include benzalkonium chloride, disodium ethylenediaminetetraacetate, dodecyl maltoside, sodium chloride, and purified water.¹

The active ingredient in OPVEE® is nalmefene, whereas the active ingredient in NARCAN® is naloxone. OPVEE® is the first nasal rescue medicine to utilize nalmefene.^1,3,4

No, the active ingredient in OPVEE® is nalmefene, which is different than naloxone.^1,3

Store OPVEE® in the blister and cartons provided.¹

Store OPVEE® at controlled room temperature 15 °C to 25 °C (59 °F to 77 °F). Short-term excursions of no more than 24 hours are permitted between 4 °C to 40 °C (39 °F to 104 °F). Do not freeze. Protect from light.¹

Do not open individual blister packs or test nasal spray devices before use.¹

Each unit-dose nasal spray device sprays one (1) time and cannot be reused.¹

OPVEE® has a 36-month shelf life from the date of manufacture.¹² Please refer to the printed date on the carton.

Learn how to order OPVEE® at OPVEEdirect.com.

Qualified direct purchasers may be eligible for public interest pricing. Product updates and additional product information are available from your representative. Reach out here to be connected to an Indivior representative today.

Qualifying direct purchasers, such as departments of health, emergency medical services, law enforcement, schools/universities, and community organizations, may be eligible to purchase OPVEE® at the public interest price, which is $37.50/dose or $75/2-pack (as of October 11, 2024). For other orders, the Wholesale Acquisition Cost (WAC)* of OPVEE® is $49/dose or $98/2-pack (as of October 11, 2024).